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Asthma During Pregnancy Linked to Disease in Offspring

Higher risk of infectious and respiratory diseases

MONDAY, Aug. 5 (HealthDay News) -- Asthma during pregnancy is associated with an increased risk of diseases in offspring, such as infectious and respiratory diseases, according to a study published online Aug. 5 in Pediatrics.

Marion Tegethoff, Ph.D., from the University of Basel in Switzerland, and colleagues examined the association between asthma during pregnancy and offspring diseases in 66,712 mother-child pairs (born between 1996 and 2002) from the Danish National Birth Cohort, where 6.2 percent of women suffered from asthma during pregnancy.

The researchers found that, after controlling for potential confounders, asthma during pregnancy was associated with an increased risk of offspring with infectious and parasitic diseases (hazard ratio [HR], 1.34), and diseases of the nervous system (HR, 1.43), ear (HR, 1.33), respiratory system (HR, 1.43), and skin (HR, 1.39). There was also a potential association with an increased risk of endocrine and metabolic disorders, diseases of the digestive system, and malformations.

"In line with previous data on selected outcomes, asthma during pregnancy may be a risk factor for numerous offspring diseases, suggesting that careful monitoring of women with asthma during pregnancy and their offspring is important," Tegethoff and colleagues conclude.

Abstract (http://pediatrics.aappublications.org/content/early/2013/07/31/peds.2012-3686.abstract )Full Text (subscription or payment may be required) (http://pediatrics.aappublications.org/content/early/2013/07/31/peds.2012-3686.full.pdf+html )