Ewing sarcoma is a cancerous bone tumor that may occur in any bone in the body. When it occurs in soft tissue, it is called extraosseous sarcoma. The most commonly affected areas include the pelvis, thigh, lower leg, upper arm, and chest wall.
The causes of Ewing sarcoma are not fully understood. Chromosomal rearrangement that alters the genes may be a factor.
Because the causes of the cancer are unknown, risk factors are also not fully understood. Ewing sarcoma appears to be more common in Caucasians, teenagers, and males.
- Pain, redness, and swelling surrounding the tumor
- Weight loss and reduced appetite
- Numbness, tingling, and paralysis
- Difficulty breathing
You will be asked about your symptoms and medical history. A physical exam will be done. You will be treated by a team of doctors which may include an oncologist who specializes in cancer, an orthopaedic surgeon who operates on bones, and a radiation oncologist who works with radiation to kill cancer cells.
Your bodily structures may need to be viewed. This can be done with:
Your bodily fluids and tissues may need to be tested. This can be done with:
- Blood tests
Treatment involves a combination of chemotherapy, surgery, and radiation. Typically, patients are first treated with chemotherapy for 8-12 weeks, followed by a CT or MRI scan to evaluate the tumor. Depending on the tumor size and location, either surgery or radiation therapy follows. Chemotherapy then resumes for several months after surgery or radiation therapy.
Chemotherapy drugs are used to kill tumor cells. Your doctor will prescribe a combination of drugs to be given over a set time. This usually means every 2-4 weeks for several months.
Surgery may be used to remove the tumor, as well as rebuild the affected bone. Depending on the location of the tumor, a bone graft or prosthesis may be needed. There are special types of prostheses that expand as the bone grows. Sometimes, several surgeries are needed to make sure the limb functions properly.
Radiation therapy uses high-energy x-rays to kill tumor cells. It may be used with surgery or instead of surgery. It is usually given over several weeks and is followed by chemotherapy.
A combination of high-dose chemotherapy and stem cell transplant is being evaluated at certain cancer centers. This combination therapy is typically used in cases where the tumor is resistant.
- Reviewer: Mohei Abouzied, MD
- Review Date: 06/2016 -
- Update Date: 05/28/2014 -